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In the US, Marinol is a prescription drug available. Dronabinol, which is a synthetic compound similar to natural THC, is the common name for Marinol. The difference between the origin of THC and dronabinol is that THC occurs in plants, and the origin of dronabinol occurs in a laboratory or chemical factory. If you’re looking for more tips, CBD has it for you.
Unimed Pharmaceuticals manufactures Marinol from pure dronabinol to prevent illicit drugs in the US. Natural marijuana is federally illegal, so it would be difficult to turn it into a drug and then have it scheduled by the DEA because of that. Unimed went through the FDA’s 3 stages of new drug approval in the 1980’s. Normally, this takes an average of 5 years, but it only took 2 years for Unimed.
Initially, Marinol was approved by the FDA for nausea and vomiting control with cancer chemotherapy back in 1985. Unimed finally obtained additional permission for the management of AIDS waste in 1992. It took two small trials, 3 years, and $5 million for this additional approval. In the world of additional software, a big bargain.
Dronabinol is a hard substance for the bloodstream to enter. It does not dissolve in water quickly, so it does not absorb a lot of it. Probably, the liver assumes that dronabinol is a contaminant and keeps some of it out of the bloodstream. The end result is that cannabinoid receptors are currently reached by just 10-20 percent.
It takes approximately 2 to 4 hours for Marinol to take effect. In a matter of minutes, smoked marijuana takes effect. Dronabinol’s side effects include anxiety, confusion, sleepiness, dizziness and changes in mood. Most patients have these consequences, and the rest will continue treatment as well.
Back in the 1970s, the National Cancer Institute sponsored many of the marijuana research that contributed greatly to the approval of Unimed by the FDA. Marinol was originally listed as a Schedule II drug by the DEA. Unimed was then willing, in 1999, to get the DEA to reprogram Marinol to Schedule III. Two things went this direction. First, it made it easier to do research, and second, it made prescribing (less paperwork) easier for doctors.